IL-24→Morpholines→Cisplatin→poly-ADP-ribose

• 18059175(IL-24): Development of Ad-mda7/IL-24-resistant lung cancer cell lines.

  In developing adenoviral mda-7 / IL-24 (Ad-mda-7 / IL-24) therapy for lung cancer , we have anticipated this potential clinical problem by attempting to identify the molecular mechanisms of Ad-mda7 / IL-24 resistance in several Ad-mda7 / IL-24-resistant lung cancer cell lines that we have developed.

• 18852117(Morpholines): A genomic approach to identify molecular pathways associated with chemotherapy resistance.

  Analysis of the lung cancer cell lines identified the bcl-2 pathway to be associated with cisplatin resistance and the AKT pathway enriched in cisplatin - and docetaxel-resistant cell lines.

• 1315778(Cisplatin): Participation of poly(ADP-ribose) polymerase in the drug sensitivity in human lung cancer cell lines.

  Among nine cell lines of lung cancer tested , small-cell lung cancer lines , which showed higher sensitivity to cisplatin and etoposide , were unexpectedly found to contain significantly higher poly (ADP-ribose) polymerase activity than five non-small-cell lung cancer cell lines.

• 11420111(poly-ADP-ribose): Characterization of poly(ADP-ribose)polymerase from Crithidia fasciculata: enzyme inhibition by beta-lapachone.

  Crithidia fasciculata poly (ADP-ribose) polymerase (PARP) has been isolated and partially purified.