IGF-1→Poly(ADP-ribose) Polymerases→Histones→poly-ADP-ribose

• 18059474(IGF-1): Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance.

  After partial hepatectomy , liver regeneration was significantly delayed.

• 1429210(Poly(ADP-ribose) Polymerases): Delayed DNA synthesis induced by 3-aminobenzamide in partially hepatectomized liver of rats.

  The possibility of poly (ADP-ribosyl) ation playing a role during liver regeneration induced by partial hepatectomy (PH) in vivo was examined.

• 1549180(Histones): Role of poly(ADP-ribose) formation in DNA repair.

  The abundant nuclear enzyme poly (ADP-ribose) polymerase catalyses the synthesis of poly (ADP-ribose) from nicotinamide adenine dinucleotide (NAD +).

• 3000421(poly-ADP-ribose): Nonenzymic adenosine 5'-diphosphate ribosylation of poly(adenosine diphosphate ribose).

  Poly (adenosine 5 ' - diphosphate ribose) (poly (ADP-ribose)) is spontaneously ADP-ribosylated when it is incubated with nicotinamide adenine dinucleotide , especially in 0.5 M NaCl and at an alkaline pH..