IL-13→Interleukin-13→Alanine→poly-ADP-ribose

• 18296657(IL-13): Association of CTLA-4 and IL-13 gene polymorphisms with Graves' disease and ophthalmopathy in Chinese children.

  This study was conducted to investigate CTLA-4 and IL-13 polymorphisms in Chinese pediatric patients with GD and GO.

• 15483090(Interleukin-13): Interleukin-13 gene polymorphisms confer the susceptibility of Japanese populations to Graves' disease.

  IL-13 gene polymorphisms were studied in Japanese GD patients (n = 310) and healthy control subjects without antithyroid autoantibodies or a family history of autoimmune disorders (n = 244).

• 19030862(Alanine): The Val762Ala polymorphism in the poly(ADP-ribose) polymerase-1 gene is not associated with susceptibility in Turkish rheumatoid arthritis patients.

  The results of the study indicate that , for our Turkish sample , the V762A polymorphism of the PARP-1 may not be involved in susceptibility to RA , implying that the polymorphism may not function as a candidate gene marker for screening RA patients.

• 15293985(poly-ADP-ribose): Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase.

  A novel class of quinazolinone derivatives as potent poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors has been discovered.