SFRP1→ADP Ribose Transferases→Bromodeoxyuridine→poly-ADP-ribose

• 18322704(SFRP1): Inhibition of myoblast differentiation by Sfrp1 and Sfrp2.

  We conclude that Sfrp1 and Sfrp2 act to prevent myoblasts from entering the terminal differentiation process.

• 1612127(ADP Ribose Transferases): Effect of an arginine-specific ADP-ribosyltransferase inhibitor on differentiation of embryonic chick skeletal muscle cells in culture.

  MIBG reversibly inhibited both proliferation and differentiation of embryonic chick myoblasts grown in culture.

• 2538435(Bromodeoxyuridine): Quantitative studies of inhibitors of ADP-ribosylation in vitro and in vivo.

  For seven of the best inhibitors , inhibition of poly (ADP-ribose) polymerase in intact C3H1OT1/2 cells was studied as a function of the inhibitor concentration of the culture medium , and the concentration for 50 % inhibition (culture medium IC50) was determined.

• 9521710(poly-ADP-ribose): Inhibitor and NAD+ binding to poly(ADP-ribose) polymerase as derived from crystal structures and homology modeling.

  Inhibitors of poly (ADP-ribose) polymerase (PARP , EC 2.4.2.30) are of clinical interest because they have potential for improving radiation therapy and chemotherapy of cancer.