IL-24→Tumor Suppressor Protein p53→Radiation-Sensitizing Agents→poly-ADP-ribose

• 18376144(IL-24): MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors.

  Infusion of Ad.mda-7 into pre-formed glioma tumors caused a rapid decrease in proliferation and blood vessel density and an increase in cell killing.

• 14508103(Tumor Suppressor Protein p53): mda-7 (IL-24) Inhibits growth and enhances radiosensitivity of glioma cells in vitro via JNK signaling.

  Ad.mda-7 reduced the proliferation of rodent and human glioma cells in MTT assays and in colony formation assays.

• 15036647(Radiation-Sensitizing Agents): Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase.

  Inhibition of poly (ADP-ribose) polymerase (PARP) by a novel , potent inhibitor , INO-1001 , was examined in two rodent and one human fibroblast cell lines , after single and fractionated radiation treatments.

• 20420408(poly-ADP-ribose): Conserved structural motif for recognizing nicotinamide adenine dinucleotide in poly(ADP-ribose) polymerases and ADP-ribosylating toxins: implications for structure-based drug design.

  The ADP-ribosylating toxins (ADPRTs) and poly (ADP-ribose) polymerases (PARPs) are two important drug-target protein families.