-
18454664(IL-1+beta): The evaluation of cystatin C, IL-1beta, and TNF-alpha levels in total saliva and gingival crevicular fluid from 11- to 16-year-old children.
Unstimulated total saliva and GCF samples were obtained.
-
8537867(Interleukin-1): Levels of interleukin-1 beta and interleukin-8 in gingival crevicular fluids in adult periodontitis.
IL-1 beta concentrations and total amounts were also positively related to IL-8 suggesting that the GCF IL-8 levels are influenced by local IL-1 beta activities.
-
7877078(Collagenases): Interleukin-1 beta stimulates collagenase production by cultured human periodontal ligament fibroblasts.
IL-1 beta induced a approximately 2.4 to 5.2-fold increase in collagenase activity in PLF compared to a approximately 1.4 to 2.2-fold increase in GF.
-
8835300(poly-ADP-ribose): Inhibition of the induction of collagenase by interleukin-1 beta in cultured rabbit synovial fibroblasts after treatment with the poly(ADP-ribose)-polymerase inhibitor 3-aminobenzamide.
We concluded that poly (ADP-ribosyl) ation plays a role in the induction of the expression of collagenase and that 3-aminobenzamide can inhibit this process.