IGF-1→Receptors, Interleukin-1→Interleukin-1→poly-ADP-ribose

• 18464249(IGF-1): Chemotaxis of human articular chondrocytes and mesenchymal stem cells.

  PDGF is the most potent factor analyzed , and may be useful to promote tissue integration during cartilage repair or tissue engineering.

• 8581744(Receptors, Interleukin-1): Modulation of interleukin-1 receptor expression by transforming growth factor-beta in cultured rabbit articular chondrocytes: analysis by reverse transcription-polymerase chain reaction.

  These results suggest that TGF beta-induced down-regulation of IL-1 RI could be responsible for its ability to antagonize the effect of IL-1 and that TGF beta may have a role in the repair of articular cartilage.

• 8424835(Interleukin-1): Transforming growth factor beta exerts opposite effects from interleukin-1 beta on cultured rabbit articular chondrocytes through reduction of interleukin-1 receptor expression.

  OBJECTIVE : The aim of the study was to determine whether transforming growth factor beta (TGF beta) modulates the effects and the receptor expression of interleukin-1 (IL-1) in rabbit articular chondrocytes (RAC).

• 8835300(poly-ADP-ribose): Inhibition of the induction of collagenase by interleukin-1 beta in cultured rabbit synovial fibroblasts after treatment with the poly(ADP-ribose)-polymerase inhibitor 3-aminobenzamide.

  In concentrations from 3 to 10 mM it reduced the collagenase activity in culture supernatants of interleukin-1 beta-stimulated rabbit synovial fibroblasts.