IL-1 beta→Antigens, CD28→Ki-67 Antigen→poly-ADP-ribose

• 18603357(IL-1+beta): Interaction between interleukin-1beta -31T/C gene polymorphism and drinking and smoking habits on the risk of hepatocellular carcinoma among Japanese.

  The risk of hepatocellular carcinoma (HCC) increases with the severity of hepatic inflammation.

• 15760554(Antigens, CD28): [The prognostic value of cellular immunity function in patients with hepatocellular carcinoma]

  OBJECTIVES : To study the changes of cellular immunity function in patients with hepatocellular carcinoma (HCC) and its correlation with disease severity.

• 11339428(Ki-67 Antigen): Enhanced polyadenosine diphosphate-ribosylation in cirrhotic liver and carcinoma tissues in patients with hepatocellular carcinoma.

  AIM : The aim of this study is to assess the poly ADP-ribosylation activity in human hepatocellular carcinoma (HCC) and in liver cirrhosis (LC) as compared to the activity in normal livers (NL).

• 3000421(poly-ADP-ribose): Nonenzymic adenosine 5'-diphosphate ribosylation of poly(adenosine diphosphate ribose).

  Poly (adenosine 5 ' - diphosphate ribose) (poly (ADP-ribose)) is spontaneously ADP-ribosylated when it is incubated with nicotinamide adenine dinucleotide , especially in 0.5 M NaCl and at an alkaline pH..