MCP1→Isoquinolines→NAD→poly-ADP-ribose

• 18657091(MCP1): A Role for galectin-3 in renal tissue damage triggered by ischemia and reperfusion injury.

  Morphometric analyses were performed at 6 , 24 , 48 and 120 h after reperfusion.

• 10744621(Isoquinolines): Inhibitors of poly (ADP-ribose) synthetase reduce renal ischemia-reperfusion injury in the anesthetized rat in vivo.

  Both renal damage and PARS activation were attenuated by administration of PARS inhibitors during reperfusion.

• 15075179(NAD): Poly(ADP-ribose) polymerase and renal hypothermic preservation injury.

  PARP enzyme activity rose quickly after reperfusion in buffer and was not different when whole blood was used.

• 11420111(poly-ADP-ribose): Characterization of poly(ADP-ribose)polymerase from Crithidia fasciculata: enzyme inhibition by beta-lapachone.

  beta-Lapachone inhibited PARP , apparently by direct interaction with the enzyme.