IGF-1→Superoxide Dismutase→Amphetamines→poly-ADP-ribose

• 18997009(IGF-1): T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS.

  Innate and adaptive immunity were investigated in the CNS of the Superoxide Dismutase 1 (SOD1) (G93A) transgenic mouse model of ALS.

• 19752764(Superoxide Dismutase): Mutant SOD1 G93A microglia have an inflammatory phenotype and elevated production of MCP-1.

  This novel finding implicates ALS microglia as a source of the increased monocyte chemoattractant protein-1 levels detected in ALS patients and in the ALS mouse model.

• 11259130(Amphetamines): Effects of an inhibitor of poly(ADP-ribose) polymerase, desmethylselegiline, trientine, and lipoic acid in transgenic ALS mice.

  A novel inhibitor of poly (ADP-ribose) polymerase showed no effects on survival.

• 15293985(poly-ADP-ribose): Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase.

  A novel class of quinazolinone derivatives as potent poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors has been discovered.