MCP1→Interleukin-1→Interleukin-1→poly-ADP-ribose

• 19008128(MCP1): Characterisation of Interleukin-8 and monocyte chemoattractant protein-1 expression within the abdominal aortic aneurysm and their association with mural inflammation.

  MCP-1 was predominantly expressed by CD68 (+) macrophages.

• 11317664(Interleukin-1): Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells.

  The production of MCP-1 by pancreatic beta cells could contribute to the recruitment of mononuclear cells into pancreatic islets in early Type I diabetes.

• 1772965(Interleukin-1): Repetitive exposure of pancreatic islets to interleukin-1 beta. An in vitro model of pre-diabetes?

  These findings may contribute to our understanding of islet cell behavior before and during onset of Type 1 diabetes.

• 2939000(poly-ADP-ribose): Long-term effects of exposure of pancreatic islets to nicotinamide in vitro on DNA synthesis, metabolism and B-cell function.

  The findings support the view that poly (ADP-ribose) synthetase inhibitors stimulate islet cell replication , but may be accompanied by significant inhibitory effects on islet cell function.