MCP1→Interleukin-1→1-Naphthylamine→poly-ADP-ribose

• 19010691(MCP1): IL-10 deficiency augments acute lung but not liver injury in hemorrhagic shock.

  In IL-10 KO mice , pulmonary MPO activity was significantly increased 3 h following resuscitation and after 24 h histological signs of acute lung injury were more apparent than in C57/BL6 mice.

• 11490123(Interleukin-1): Attenuation of liver and lung injury after hepatic ischemia and reperfusion by a cytokine-suppressive agent, FR167653.

  These cytokines play important roles in the induction of polymorphonuclear neutrophil (PMN) activation and infiltration , and induce not only localized hepatic injury but also remote organ injury , especially pulmonary injury.

• 12686864(1-Naphthylamine): The effect of poly (adenosine diphosphate-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury.

  PURPOSE : Poly (adenosine diphosphate (ADP) - ribose) polymerase inhibitors have been used successfully to decrease ischemia-reperfusion injury in several organ systems.

• 3000421(poly-ADP-ribose): Nonenzymic adenosine 5'-diphosphate ribosylation of poly(adenosine diphosphate ribose).

  Poly (adenosine 5 ' - diphosphate ribose) (poly (ADP-ribose)) is spontaneously ADP-ribosylated when it is incubated with nicotinamide adenine dinucleotide , especially in 0.5 M NaCl and at an alkaline pH..