IL-6→Chemokine CCL2→Poly(ADP-ribose) Polymerases→1-Naphthylamine→poly-ADP-ribose

• 19166837(IL-6): Simvastatin reduces secondary brain injury caused by cortical contusion in rats: possible involvement of TLR4/NF-kappaB pathway.

  This study was undertaken to evaluate the effect of simvastatin on the Toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-kappaB) related signaling pathway and secondary brain injury in rats after traumatic brain injury (TBI).

• 20029451(Chemokine CCL2): Role of CCL2 (MCP-1) in traumatic brain injury (TBI): evidence from severe TBI patients and CCL2-/- mice.

  Cerebral inflammation involves molecular cascades contributing to progressive damage after traumatic brain injury (TBI).

• 11450092(Poly(ADP-ribose) Polymerases): Traumatic brain injury in mice deficient in poly-ADP(ribose) polymerase: a preliminary report.

  PARP contributes to neuronal cell death in vivo after cerebral ischemia/reperfusion , however , the role of PARP in the pathogenesis of traumatic brain injury (TBI) is unknown.

• 12686864(1-Naphthylamine): The effect of poly (adenosine diphosphate-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury.

  PURPOSE : Poly (adenosine diphosphate (ADP) - ribose) polymerase inhibitors have been used successfully to decrease ischemia-reperfusion injury in several organ systems.

• 3000421(poly-ADP-ribose): Nonenzymic adenosine 5'-diphosphate ribosylation of poly(adenosine diphosphate ribose).

  Poly (adenosine 5 ' - diphosphate ribose) (poly (ADP-ribose)) is spontaneously ADP-ribosylated when it is incubated with nicotinamide adenine dinucleotide , especially in 0.5 M NaCl and at an alkaline pH..