matrix metalloproteinase→Transcription Factor AP-1→Matrix Metalloproteinase 2→Indoles→poly-ADP-ribose

• 19216640(matrix+metalloproteinase): Controlled release of matrix metalloproteinase 1 with or without skeletal myoblasts transplantation improves cardiac function of rat hearts with chronic myocardial infarction.

  Matrix metalloproteinase 1 (MMP-1) reduces fibrosis and prevents the progress of heart failure.

• 19576087(Transcription Factor AP-1): [The expression and significance of activator protein-1 and matrix metalloproteinases in the human heart post acute myocardial infarction]

  (2) The level of MMP-9 expression was significantly and positively correlated with c-Jun in AMI heart tissue (r = 0.773 , P (0.01).

• 12031700(Matrix Metalloproteinase 2): Myocardial protection from ischemia/reperfusion injury by targeted deletion of matrix metalloproteinase-9.

  Targeted deletion of MMP-9 protected the heart from no-flow ischemia-reperfusion-induced myocardial injury.

• 14770035(Indoles): Activation of poly(ADP-ribose) polymerase in circulating leukocytes during myocardial infarction.

  Oxidant-mediated DNA single strand breaks are known to activate the nuclear enzyme poly (ADP-ribose) polymerase (PARP) in various forms of shock , inflammation , and ischemia-reperfusion injury.

• 11420111(poly-ADP-ribose): Characterization of poly(ADP-ribose)polymerase from Crithidia fasciculata: enzyme inhibition by beta-lapachone.

  Crithidia fasciculata poly (ADP-ribose) polymerase (PARP) has been isolated and partially purified.