IL-1 beta→Isoquinolines→NAD→poly-ADP-ribose

• 19265174(IL-1+beta): Role of proinflammatory cytokines IL-18 and IL-1beta in bleomycin-induced lung injury in humans and mice.

  To support the data obtained from patient samples , the levels of IL-1beta and IL-18 mRNA and protein , pulmonary inflammation , and lung fibrosis were examined in mouse models of bleomycin-induced lung injury.

• 15644425(Isoquinolines): Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and the development of bleomycin-induced lung injury.

  Poly (ADP-ribose) polymerase (PARP) , a nuclear enzyme activated by strand breaks in DNA , plays an important role in the tissue injury associated with inflammation.

• 1663835(NAD): Inhibition of topoisomerase I by NAD and enhancement of cytotoxicity of MMS by inhibitors of poly(ADP-ribose) polymerase in Saccharomyces cerevisiae.

  The activity of DNA topoisomerase I present in the nuclear extract of yeast , Saccharomyces cerevisiae , was inhibited by additions of NAD , the substrate of poly (ADP-ribose) polymerase.

• 10623965(poly-ADP-ribose): [Enzymatic synthesis of beta-NAD+ selectively marked with tritium at adenine and its use for determining the activity of poly(ADP-ribose) polymerase]

  The tritiated NAD prepared by this method can be used in the quantitative assay of the chromatin enzyme poly (ADP-ribose) polymerase.