IL-1 beta→Isoquinolines→Vascular Endothelial Growth Factor A→poly-ADP-ribose

• 19265174(IL-1+beta): Role of proinflammatory cytokines IL-18 and IL-1beta in bleomycin-induced lung injury in humans and mice.

  To support the data obtained from patient samples , the levels of IL-1beta and IL-18 mRNA and protein , pulmonary inflammation , and lung fibrosis were examined in mouse models of bleomycin-induced lung injury.

• 15644425(Isoquinolines): Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and the development of bleomycin-induced lung injury.

  Poly (ADP-ribose) polymerase (PARP) , a nuclear enzyme activated by strand breaks in DNA , plays an important role in the tissue injury associated with inflammation.

• 17714938(Vascular Endothelial Growth Factor A): Poly(ADP-ribose) polymerase (PARP) inhibition or PARP-1 gene deletion reduces angiogenesis.

  Poly (ADP-ribose) polymerase (PARP) -1 has recently been shown to promote tumor progression.

• 11420111(poly-ADP-ribose): Characterization of poly(ADP-ribose)polymerase from Crithidia fasciculata: enzyme inhibition by beta-lapachone.

  Crithidia fasciculata poly (ADP-ribose) polymerase (PARP) has been isolated and partially purified.