matrix metalloproteinase→Cytokines→14-3-3 Proteins→poly-ADP-ribose

• 19464272(matrix+metalloproteinase): Quantitative analyses of matrix metalloproteinase activity after traumatic brain injury in adult rats.

  Recent laboratory evidence implicates matrix metalloproteinases (MMPs) as playing a pivotal role in ischemic and traumatic brain injuries (TBI).

• 19125683(Cytokines): Role of Nrf2 in protection against traumatic brain injury in mice.

  The present study investigated the role of Nrf2 in modulating traumatic brain injury (TBI) - induced secondary brain injury.

• 12694396(14-3-3 Proteins): A dual role for poly-ADP-ribosylation in spatial memory acquisition after traumatic brain injury in mice involving NAD+ depletion and ribosylation of 14-3-3gamma.

  Poly (ADP-ribose) polymerase-1 (PARP-1) is a homeostatic enzyme that paradoxically contributes to disturbances in spatial memory acquisition after traumatic brain injury (TBI) in transgenic mice , thought to be related to depletion of its substrate nicotinamide adenine dinucleotide (NAD +).

• 6314820(poly-ADP-ribose): NAD+-dependent ADP-ribosyltransferase in renal brush-border membranes.

  Oxidized nicotinamide adenine dinucleotide (NAD +) in cytosol may interact with renal brush-border membranes (BBM) and inhibit BBM phosphate transport.