matrix metalloproteinase→Matrix Metalloproteinases→Tumor Necrosis Factor-alpha→poly-ADP-ribose

• 19466518(matrix+metalloproteinase): Matrix metalloproteinase-1 and -2 levels are differently regulated in acute exacerbation of heart failure in patients with and without left ventricular systolic dysfunction.

  Serum MMP-1 and MMP-2 , and plasma brain natriuretic peptide (BNP) levels were examined on admission and at discharge.

• 11216828(Matrix Metalloproteinases): Expression of matrix metalloproteinases in patients with acute myocardial infarction.

  In conclusion , plasma MMP-2 levels and activity and MMP-1 production by PBMCs are increased in patients with AMI.

• 17689746(Tumor Necrosis Factor-alpha): Acute myocardial infarction induced increases in plasma tumor necrosis factor-alpha and interleukin-10 are associated with the activation of poly(ADP-ribose) polymerase of circulating mononuclear cell.

  These results implicated that activation of PARP in MNC contributes to the increases in plasma TNF-alpha and IL-10 and is associated with systolic dysfunction of heart after AMI.

• 15110462(poly-ADP-ribose): Purification and properties of poly(ADP-ribose)polymerase from Crithidia fasciculata. Automodification and poly(ADP-ribosyl)ation of DNA topoisomerase I.

  This is the first PARP isolated to apparent homogeneity from trypanosomatids.