matrix metalloproteinase→Matrix Metalloproteinases→Tumor Necrosis Factor-alpha→poly-ADP-ribose

• 19466518(matrix+metalloproteinase): Matrix metalloproteinase-1 and -2 levels are differently regulated in acute exacerbation of heart failure in patients with and without left ventricular systolic dysfunction.

  Matrix metalloproteinases (MMPs) play important roles in progression of chronic heart failure (HF) by regulating cardiac extracellular matrix metabolism.

• 11216828(Matrix Metalloproteinases): Expression of matrix metalloproteinases in patients with acute myocardial infarction.

  This study investigated the clinical significance of matrix metalloproteinases (MMPs) in acute myocardial infarction (AMI) and the involvement of peripheral blood mononuclear cells (PBMCs) , which are a possible source of MMPs in AMI.

• 17689746(Tumor Necrosis Factor-alpha): Acute myocardial infarction induced increases in plasma tumor necrosis factor-alpha and interleukin-10 are associated with the activation of poly(ADP-ribose) polymerase of circulating mononuclear cell.

  In this study , we proved that poly (ADP-ribose) polymerase (PARP) activity of circulating mononuclear cell (MNC) increased significantly in post-AMI patients.

• 188648(poly-ADP-ribose): Purification of poly(ADP-ribose) polymerase from Ehrlich ascites tumor cells by chromatography on DNA-agarose.

  Electrophoretic analysis indicated that the preparation contained two proteins , one of which was shown to catalyze the synthesis of poly (ADP-ribose).