IL-6→Nitric Oxide→Hydrogen Peroxide→poly-ADP-ribose

• 19505765(IL-6): Intra-alveolar IL-6 levels following burn and inhalation injury.

  These levels of IL-6 were reduced when associated with either inhalation injury or burn , but were increased when the traumas were combined.

• 12626333(Nitric Oxide): Effect of poly(ADP ribose) synthetase inhibition on burn and smoke inhalation injury in sheep.

  We investigated the role of the nuclear enzyme poly (ADP ribose) synthetase (PARS) in the pathogenesis of combined burn and smoke inhalation (burn/smoke) injury in an ovine model.

• 7643121(Hydrogen Peroxide): Poly(ADP-ribose) synthetase activation: an early indicator of neurotoxic DNA damage.

  DNA damage activates a nuclear enzyme poly (ADP-ribose) synthetase (PARS) that facilitates DNA repair by adding multiple ADP-ribose groups to nuclear proteins such as histones and PARS itself.

• 6316953(poly-ADP-ribose): Involvement of polyADP-ribose polymerase in the initiation of phytohemagglutinin induced human lymphocyte proliferation.

  When the inhibitors of poly (ADPR) polymerase are added at a later stage of culture (48 h) no inhibition of the stimulation of DNA synthesis and cell proliferation by PHA in human lymphocyte cultures is observed.