IL-8→Chemokine CCL2→Poly(ADP-ribose) Polymerases→poly-ADP-ribose

• 19509619(IL-8): Serum IL-8 and MCP-1 concentration do not identify patients with enlarging contusions after traumatic brain injury.

  CONCLUSIONS : These inflammatory mediators may be predictive of a poor outcome in patients with traumatic brain injury in which contusions are the predominant abnormality.

• 20029451(Chemokine CCL2): Role of CCL2 (MCP-1) in traumatic brain injury (TBI): evidence from severe TBI patients and CCL2-/- mice.

  Cerebral inflammation involves molecular cascades contributing to progressive damage after traumatic brain injury (TBI).

• 11450092(Poly(ADP-ribose) Polymerases): Traumatic brain injury in mice deficient in poly-ADP(ribose) polymerase: a preliminary report.

  PARP contributes to neuronal cell death in vivo after cerebral ischemia/reperfusion , however , the role of PARP in the pathogenesis of traumatic brain injury (TBI) is unknown.

• 11420111(poly-ADP-ribose): Characterization of poly(ADP-ribose)polymerase from Crithidia fasciculata: enzyme inhibition by beta-lapachone.

  beta-Lapachone inhibited PARP , apparently by direct interaction with the enzyme.