IFN-gamma→Caspase 3→1-Naphthylamine→poly-ADP-ribose

• 19514843(IFN-gamma): Protective effect of new nitrosothiols on the early inflammatory response to kidney ischemia/reperfusion and transplantation in rats.

  Warm ischemia was achieved by ligation of left renal pedicle for 60 min , followed by contralateral nephrectomy.

• 15496312(Caspase 3): Differential effects of caspase inhibitors on the renal dysfunction and injury caused by ischemia-reperfusion of the rat kidney.

  Here , we investigate the effects of different caspase inhibitors on the renal dysfunction and injury caused by ischemia-reperfusion of the rat kidney.

• 12686864(1-Naphthylamine): The effect of poly (adenosine diphosphate-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury.

  PURPOSE : Poly (adenosine diphosphate (ADP) - ribose) polymerase inhibitors have been used successfully to decrease ischemia-reperfusion injury in several organ systems.

• 3000421(poly-ADP-ribose): Nonenzymic adenosine 5'-diphosphate ribosylation of poly(adenosine diphosphate ribose).

  Poly (adenosine 5 ' - diphosphate ribose) (poly (ADP-ribose)) is spontaneously ADP-ribosylated when it is incubated with nicotinamide adenine dinucleotide , especially in 0.5 M NaCl and at an alkaline pH..