MCP1→Intercellular Adhesion Molecule-1→Intercellular Adhesion Molecule-1→poly-ADP-ribose

• 19582157(MCP1): Absence of p55 TNF receptor reduces atherosclerosis, but has no major effect on angiotensin II induced aneurysms in LDL receptor deficient mice.

  BACKGROUND : The aim of the current study was to investigate the role of p55 TNF Receptor (p55 TNFR) , the main signaling receptor for the pro-inflammatory cytokine tumor necrosis factor (TNF) , in the development of two vascular disorders : atherosclerosis and angiotensin (Ang) II-induced abdominal aortic aneurysms (AAA).

• 7955542(Intercellular Adhesion Molecule-1): Intercellular adhesion molecule-1 (ICAM-1) expression and soluble ICAM-1 (sICAM-1) production by cytokine-activated human aortic endothelial cells: a possible role for ICAM-1 and sICAM-1 in atherosclerotic aortic aneurysms.

  The interactions of inflammatory cells , cytokines , and cell adhesion molecules (CAM) may be important in the pathogenesis of vascular diseases such as abdominal aortic aneurysms (AAA) , in which inflammation plays a role.

• 9670921(Intercellular Adhesion Molecule-1): Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury.

  The nuclear enzyme poly (ADP-ribose) synthetase (PARS) has been shown to play an important role in the pathogenesis of ischemia/reperfusion injury and circulatory shock.

• 8080500(poly-ADP-ribose): Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity.

  Poly (adenosine 5 ' - diphosphoribose) synthetase (PARS) is a nuclear enzyme which , when activated by DNA strand breaks , adds up to 100 adenosine 5 ' - diphosphoribose (ADP-ribose) units to nuclear proteins such as histones and PARS itself.