matrix metalloproteinase→Matrix Metalloproteinase 2→Catecholamines→poly-ADP-ribose

• 19595140(matrix+metalloproteinase): [Correlation between expressions of matrix metalloproteinase-2 & 9 and vasculogenic mimicry in gastrointestinal stromal tumors]

  CONCLUSION : The expression of MMP-2 and MMP-9 correlates with VM formation in GIST.

• 18471998(Matrix Metalloproteinase 2): Elevated circulatory MMP-2 and MMP-9 levels and activities in patients with rheumatoid arthritis and systemic lupus erythematosus.

  RESULTS : MMP-2 levels in control subjects , RA and SLE patients were 146.1 + / -34.2 , 194.0 + / -24.2 and 208.9 + / -75.9 ng/mL respectively , and for MMP-9 were 51.4 + / -57.1 , 567.7 + / -313.1 and 208.7 + / -105.5 ng/mL respectively.

• 11511755(Catecholamines): Systemic lupus erythematosus and rheumatoid arthritis patients differ from healthy controls in their cytokine pattern after stress exposure.

  CONCLUSIONS : These data demonstrate that RA and SLE patients differ in their immune response to stress from healthy controls.

• 2931521(poly-ADP-ribose): Decrease in the reaction of DNA repair synthesis in response to nicotinamide or 3-aminobenzamide in ultraviolet irradiated systemic lupus erythematosus lymphocytes.

  These data suggest that DNA repair is disturbed under special conditions in the lymphocytes of SLE patients.