CD38→Interferon-gamma, Recombinant→Interferon-gamma→poly-ADP-ribose

• 19644143(CD38): Reduced CD38 expression on CD34+ cells as a diagnostic test in myelodysplastic syndromes.

  Flow cytometry has been used to distinguish myelodysplastic syndrome from non-clonal cytopenias.

• 1943231(Interferon-gamma, Recombinant): Interferon gamma induces differentiation of cells from patients with myelodysplastic syndromes in vitro and in vivo.

  Although IFN-gamma therapy resulted in partial or minor responses , these findings suggest the potential of IFN-gamma to act as an inducer of differentiation in myelodysplastic syndromes both in vitro and in vivo.

• 6432314(Interferon-gamma): Potent activation of mouse macrophages by recombinant interferon-gamma.

  Similarly , IFN-gamma , at low concentrations , induced an inhibition of migration by macrophages.

• 1899803(poly-ADP-ribose): Activation of human monocyte-derived macrophages by interferon gamma is accompanied by increase of poly(ADP-ribose) polymerase activity.

  IFN-gamma was shown to induce DNA strand breaks in human macrophages.