IL-6→Intercellular Adhesion Molecule-1→NF-kappa B→poly-ADP-ribose

• 19698145(IL-6): Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease.

  BACKGROUND : Chronic inflammation is a characteristic of Alzheimer 's disease (AD).

• 15288699(Intercellular Adhesion Molecule-1): Monocyte chemoattractant protein-1 (MCP-1) gene polymorphism and risk of Alzheimer's disease in Italians.

  Upregulation of MCP-1 may occur in the brain of subjects affected by Alzheimer 's disease (AD) and MCP-1 levels in plasma and cerebrospinal fluid have been proposed as biological markers for the inflammatory process that accompanies AD pathogenesis.

• 12540607(NF-kappa B): Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic beta-cells.

  We have previously described cytokine-induced MCP-1 gene expression in human and rat pancreatic islets.

• 7664532(poly-ADP-ribose): Differential insulin secretory activity in rat pancreatic islets and HIT cells.

  These findings indicate that the multiple components of insulin stimulus-secretion coupling in HIT cells are considerably different from those in rat pancreatic islets.