IL-8→NF-kappa B→NF-kappa B→poly-ADP-ribose

• 19719901(IL-8): Associations of plasma IL-8 levels with Helicobacter pylori seropositivity, gastric atrophy, and IL-8 T-251A genotypes.

  Seventy-one subjects were positive for H. pylori infection.

• 10766316(NF-kappa B): Expression of nuclear factor-kappaB in Helicobacter pylori-infected gastric mucosa detected with southwestern histochemistry.

  CONCLUSIONS : H. pylori infection increases the expression of NF-kappaB in gastric mucosa , suggesting that NF-kappaB is involved in inflammatory responses to H. pylori.

• 18070899(NF-kappa B): NF-kappaB activation during acute Helicobacter pylori infection in mice.

  This work demonstrates for the first time the induction of NF-kappaB activation within gastric mucosal cells during acute H. pylori infection.

• 12581860(poly-ADP-ribose): gamma-Irradiation-induced DNA damage enhances NO production via NF-kappaB activation in RAW264.7 cells.

  Nuclear factor kappa B (NF-kappaB) activation was induced 1 h after gamma-irradiation dose-dependently , which was detected by the degradation of I-kappaB.