IFN-gamma→Tumor Necrosis Factor-alpha→Nitric Oxide→poly-ADP-ribose

• 19751227(IFN-gamma): Oral lesions in lupus erythematosus-cytokines profiles of inflammatory infiltrate.

  Other cytokines were only mildly positive.

• 7962274(Tumor Necrosis Factor-alpha): Human pancreatic islet beta-cell destruction by cytokines is independent of nitric oxide production.

  To determine the possible role of nitric oxide (NO) as a mediator of cytokine-induced islet beta-cell destruction , we studied the relationships between NO production and destruction of human pancreatic islet cells incubated with cytokines in vitro.

• 7752811(Nitric Oxide): Poly(ADP-ribose) synthesis induced by nitric oxide in a mouse beta-cell line.

  Nitric oxide (NO) has been implicated as an immunological effector molecule that mediates beta-cell dysfunction associated with Type 1 diabetes.

• 8080500(poly-ADP-ribose): Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity.

  Nitric oxide (NO) stimulated ADP-ribosylation of PARS in rat brain.