MCP1→Interleukin-1→Nitric Oxide→poly-ADP-ribose

• 19755790(MCP1): CD40 ligand and MCP-1 as predictors of cardiovascular events in diabetic patients with stroke.

  AIM : Up-regulation of soluble CD40 ligand (sCD40L) and of monocyte chemoattractant protein-1 (MCP-1) has been found in diabetes and in patients with acute cerebral ischemia.

• 11317664(Interleukin-1): Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells.

  AIMS/HYPOTHESIS : Monocyte chemoattractant protein-1 (MCP-1) attracts monocytes and T lymphocytes , and could thus contribute to mononuclear cell infiltration in Type I (insulin-dependent) diabetes mellitus.

• 7752811(Nitric Oxide): Poly(ADP-ribose) synthesis induced by nitric oxide in a mouse beta-cell line.

  Nitric oxide (NO) has been implicated as an immunological effector molecule that mediates beta-cell dysfunction associated with Type 1 diabetes.

• 8080500(poly-ADP-ribose): Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity.

  Nitric oxide (NO) stimulated ADP-ribosylation of PARS in rat brain.