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19764560(matrix+metalloproteinase): [Effect of irradiation on matrix metalloproteinases, vascular endothelial growth factor and microvessel density of mice bearing Lewis lung cancer]
RESULTS : Immunohistochemical examination demonstrated an increased expression of MMP2 , MMP9 , VEGF and MVD in the tumor tissue of the radiation group (P (0.05).
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17505006(Benzimidazoles): Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models.
Ionizing radiation induces DNA strand breaks , suggesting that PARP-1 inhibition may sensitize tumor cells to radiation.
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16391829(Poly(ADP-ribose) Polymerases): Quantitative correlation between cellular proliferation and nuclear poly (ADP-ribose) polymerase (PARP-1).
A specific inhibitor and an inactivator of PARP-1 each inhibit DNA synthesis when intact cancer cells are pretreated with these drugs.
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185509(Progesterone): Poly ADP-ribosylation of DNA-dependent RNA polymerase I from quail oviduct. Dependence on progesterone stimulation.
This increase is accompanied by a marked decrease of the specific activity of poly (ADP-Rib) polymerase.
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228176(poly-ADP-ribose): Characterisation of poly(ADP-Rib) polymerase activity in nuclei from the slime mould Dictyostelium discoideum.
The optimum incubation conditions for the poly (ADP-Rib) polymerase were determined.