MCP1→Poly(ADP-ribose) Polymerases→NAD→poly-ADP-ribose

• 20029451(MCP1): Role of CCL2 (MCP-1) in traumatic brain injury (TBI): evidence from severe TBI patients and CCL2-/- mice.

  We found that CCL2 - / - mice showed altered production of multiple cytokines acutely (2 to 24 h) ; however , this did not affect lesion size or cell death within the first week after CHI.

• 11450092(Poly(ADP-ribose) Polymerases): Traumatic brain injury in mice deficient in poly-ADP(ribose) polymerase: a preliminary report.

  Poly (ADP-ribose) polymerase (PARP) is a ubiquitous nuclear enzyme that , when activated by free-radical induced DNA damage , contributes to energy failure and cell death in models of central nervous system ischemia and reperfusion.

• 10860495(NAD): A scintillation proximity assay for poly(ADP-ribose) polymerase.

  Poly (ADP-ribose) polymerase (PARP) is an abundant nuclear protein in most of the eukaryotic tissues.

• 228176(poly-ADP-ribose): Characterisation of poly(ADP-Rib) polymerase activity in nuclei from the slime mould Dictyostelium discoideum.

  The optimum incubation conditions for the poly (ADP-Rib) polymerase were determined.