IGF-1→Dexamethasone→Phosphates→Bacterial Proteins→poly-ADP-ribose

• 20045394(IGF-1): Regulation of 11beta-hydroxysteroid dehydrogenase 1 and 2 by IGF-1 in mice.

  11beta-HSD1 is an NADP + / NADPH-dependent oxidoreductase which is mainly expressed in liver and kidney , while 11beta-HSD2 is an NAD + - dependent oxidase which is predominantly expressed in kidney.

• 9141556(Dexamethasone): Metabolism of dexamethasone in the human kidney: nicotinamide adenine dinucleotide-dependent 11beta-reduction.

  Oxidation of F to E : NAD was the exclusively used cosubstrate ; the affinity (Michael 's constant (Km) for F = 25.5 nmol/L) and the maximum velocity (Vmax = 22.9 nmol/mg/min) were high.

• 4107303(Phosphates): Studies on energy-linked reactions. Energy-linked reduction of oxidized nicotinamide-adenine dinucleotide by succinate in Escherichia coli.

  These particles catalyse the ATP-driven reduction of NAD (+) by succinate.

• 4310516(Bacterial Proteins): Replication and properties of DNA in nicotinamide adenine dinucleotide deficiency of Escherichia coli cells.

  When niacin-requiring E. coli was starved of niacin , a precursor of nicotinamide adenine dinucleotide (NAD) , the cells elongated and synthesis of DNA was inhibited while syntheses of RNA and protein continued.

• 6237718(poly-ADP-ribose): Effects of nicotinamide and structural analogs on DNA synthesis and cellular replication of rat hepatoma cells.

  The effects of nicotinamide and structural analogs on DNA synthesis were studied in rat hepatoma (HTC) cells.