IL-1 beta→Tumor Necrosis Factor-alpha→1-Naphthylamine→poly-ADP-ribose

• 20458900(IL-1+beta): [Effect of electroacupuncture on the expression of spinal glial fibrillary acidic protein, tumor necrosis factor-alpha and interleukin-1beta in chronic neuropathic pain rats]

  Compared with sham group , GFAP immunoactivity (mainly in the lamina I-II of the spinal dorsal horn) , TNF-alpha mRNA and IL-1beta mRNA expression in the ipsilateral spinal cord on the CCI side in model group increased considerably (P (0.05) , while compared with model group , the expression of GFAP , TNF-alpha mRNA and IL-1beta mRNA in EA group was down-regulated remarkably (P (0.05).

• 19847755(Tumor Necrosis Factor-alpha): Analysis of serum pro-inflammatory cytokine levels after rat spinal cord ischemia/reperfusion injury and correlation with tissue damage.

  CONCLUSION : Inflammation is a plausible pathway in spinal cord ishemia/reperfusion injury.

• 12686864(1-Naphthylamine): The effect of poly (adenosine diphosphate-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury.

  We evaluated the efficacy of poly (ADP-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury.

• 8147870(poly-ADP-ribose): Nitric oxide toxicity in islet cells involves poly(ADP-ribose) polymerase activation and concomitant NAD+ depletion.

  These findings indicate a key role of poly (ADP-ribose) polymerase activation in NO toxicity in islet cells.