matrix metalloproteinase→Niacinamide→ADP Ribose Transferases→poly-ADP-ribose

• 20496198(matrix+metalloproteinase): Pinocembrin protects the neurovascular unit by reducing inflammation and extracellular proteolysis in MCAO rats.

  Focal cerebral ischemia was induced by occlusion of middle cerebral artery (MCAO) in rats.

• 10884473(Niacinamide): Delayed treatment with nicotinamide (Vitamin B(3)) improves neurological outcome and reduces infarct volume after transient focal cerebral ischemia in Wistar rats.

  METHODS : Forty-eight male Wistar rats were used , and transient focal cerebral ischemia was induced by MCAo for 2 hours , followed by reperfusion for either 3 or 7 days.

• 10374629(ADP Ribose Transferases): Neuroprotective effects of poly (ADP-ribose) polymerase inhibitors in transient focal cerebral ischemia of rats.

  AIM : To explore the role of poly (ADP-ribose) polymerase (PARP) in focal cerebral ischemia with reperfusion injury.

• 9521710(poly-ADP-ribose): Inhibitor and NAD+ binding to poly(ADP-ribose) polymerase as derived from crystal structures and homology modeling.

  Inhibitors of poly (ADP-ribose) polymerase (PARP , EC 2.4.2.30) are of clinical interest because they have potential for improving radiation therapy and chemotherapy of cancer.