CD38→Antigens, Differentiation→Antigens, Differentiation→Membrane Glycoproteins→poly-ADP-ribose

• 7690555(CD38): Rapid induction of CD38 antigen on myeloid leukemia cells by all trans-retinoic acid.

  Virtually no information is available on the regulation and functions of CD38 antigen in hematopoietic cells.

• 8394323(Antigens, Differentiation): NAD glycohydrolase specifically induced by retinoic acid in human leukemic HL-60 cells. Identification of the NAD glycohydrolase as leukocyte cell surface antigen CD38.

  The NADase specifically induced by retinoic acid appeared to be encoded by human leukocyte cell surface antigen CD38 as follows.

• 8093047(Antigens, Differentiation): Cell surface antigen CD38 identified as ecto-enzyme of NAD glycohydrolase has hyaluronate-binding activity.

  An ecto-enzyme of NAD glycohydrolase induced by retinoic acid in human leukemic HL-60 cells is attributed to the molecule of leukocyte cell surface antigen CD38 (Kontani , K. , et al.

• 15749861(Membrane Glycoproteins): CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins.

  Upon exposure of T cells to NAD , the substrate for ADP-ribosylation , ART2 catalyzes ADP-ribosylation of the P2X7 purinoceptor and other functionally important cell surface proteins.

• 221495(poly-ADP-ribose): NAD-dependent ADP-ribosylation of arginine and proteins by Escherichia coli heat-labile enterotoxin.

  In the presence of (adenine-U-14C) NAD , E. coli enterotoxin catalyzed the transfer of the radiolabel to proteins ; the ADP-ribosylation of proteins was inhibited by arginine methyl ester , an alternative substrate.