CD38→Antibodies, Monoclonal→Cyclic ADP-Ribose→Poly(ADP-ribose) Polymerases→poly-ADP-ribose

• 7690555(CD38): Rapid induction of CD38 antigen on myeloid leukemia cells by all trans-retinoic acid.

  Using human promyelocytic leukemia cells , we demonstrate that all trans-retinoic acid is a potent and specific inducer of CD38 expression in myeloid lineage.

• 15026555(Antibodies, Monoclonal): Retinoic acid-induced CD38 antigen as a target for immunotoxin-mediated killing of leukemia cells.

  We reported previously that retinoic acid (RA) is a potent and selective inducer of the cell-surface antigen CD38 in myeloid leukemia cells.

• 15572023(Cyclic ADP-Ribose): Nuclear CD38 in retinoic acid-induced HL-60 cells.

  Thus , GDP-ribosyl cyclase and NAD (+) glycohydrolase activities in the nuclear fraction increased very significantly in response to incubation with RA.

• 1849825(Poly(ADP-ribose) Polymerases): Cellular regulation of ADP-ribosylation of proteins. IV. Conversion of poly(ADP-ribose) polymerase activity to NAD-glycohydrolase during retinoic acid-induced differentiation of HL60 cells.

  When homogenous isolated ADPRT was first ADP-ribosylated in vitro , it lost its capacity to catalyze further polymer synthesis , whereas the NAD glycohydrolase function of the automodified enzyme was greatly augmented.

• 228176(poly-ADP-ribose): Characterisation of poly(ADP-Rib) polymerase activity in nuclei from the slime mould Dictyostelium discoideum.

  The Km of the enzyme is 18 microM NAD and it is inhibited by nicotinamide.