CD38→Poly(ADP-ribose) Polymerases→Poly(ADP-ribose) Polymerases→Nucleoside Diphosphate Sugars→poly-ADP-ribose

• 8962429(CD38): Anti-CD38 prevents the development of the adaptive response induced by X-rays in human lymphocytes.

  The response was reflected in a lower micronucleus frequency but not in the DNA repair rate measured by the comet assay directly after the challenge dose.

• 2471914(Poly(ADP-ribose) Polymerases): Effect of 3-aminobenzamide on chromosome damage in human blood lymphocytes adapted to bleomycin.

  This repair process was negated when 3-amino-benzamide , an inhibitor of poly (ADP) polymerase , was added to the cultures immediately after the challenge treatment.

• 3103620(Poly(ADP-ribose) Polymerases): Cell cycle-dependent potentiation of X-ray-induced chromosomal aberrations by 3-aminobenzamide.

  These results indicate that poly (ADP-ribose) polymerase may be involved in chromosomal repair of radiation damage only during specific stages of the cell cycle.

• 2452600(Nucleoside Diphosphate Sugars): Enhancement of bleomycin activity by 3-aminobenzamide, a poly (ADP-ribose) synthesis inhibitor, in vitro and in vivo.

  The degree of inhibition of poly (ADP-ribose) synthesis by these inhibitors corresponded in general with their potentiating ability of bleomycin cytotoxicity.

• 15293985(poly-ADP-ribose): Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase.

  A novel class of quinazolinone derivatives as potent poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors has been discovered.