CD38→Poly(ADP-ribose) Polymerases→Poly(ADP-ribose) Polymerases→Nucleotidyltransferases→poly-ADP-ribose

• 8962429(CD38): Anti-CD38 prevents the development of the adaptive response induced by X-rays in human lymphocytes.

  The response was reflected in a lower micronucleus frequency but not in the DNA repair rate measured by the comet assay directly after the challenge dose.

• 2471914(Poly(ADP-ribose) Polymerases): Effect of 3-aminobenzamide on chromosome damage in human blood lymphocytes adapted to bleomycin.

  This repair process was negated when 3-amino-benzamide , an inhibitor of poly (ADP) polymerase , was added to the cultures immediately after the challenge treatment.

• 3103620(Poly(ADP-ribose) Polymerases): Cell cycle-dependent potentiation of X-ray-induced chromosomal aberrations by 3-aminobenzamide.

  These results indicate that poly (ADP-ribose) polymerase may be involved in chromosomal repair of radiation damage only during specific stages of the cell cycle.

• 2156280(Nucleotidyltransferases): [The effect of the x-ray irradiation of rats on the NAD-pyrophosphorylase and poly(ADP-ribose)polymerase activities of brain nuclei and on the NAD content in nerve tissue]

  It was shown that X-radiation was ineffective with regard to NAD-pyrophosphorylase activity of nuclei and increased their poly (ADP-ribose) polymerase activity.

• 228176(poly-ADP-ribose): Characterisation of poly(ADP-Rib) polymerase activity in nuclei from the slime mould Dictyostelium discoideum.

  The optimum incubation conditions for the poly (ADP-Rib) polymerase were determined.