stanniocalcin→Neoplasm Proteins→Poly(ADP-ribose) Polymerases→NAD→poly-ADP-ribose

• 9027337(stanniocalcin): Molecular cloning and characterization of mouse stanniocalcin cDNA.

  To facilitate studies of the function of stanniocalcin in mammals , we have now isolated the mouse stanniocalcin cDNA.

• 1398148(Neoplasm Proteins): Cloning and sequencing of a cDNA encoding mouse stromelysin 1.

  A cDNA encoding mouse stromelysin 1 was cloned and the 1740-bp sequence was determined.

• 2498841(Poly(ADP-ribose) Polymerases): Sequence and organization of the mouse poly (ADP-ribose) polymerase gene.

  Using a human cDNA probe , we have isolated murine genomic and cDNA clones corresponding to the nuclear enzyme poly (ADP-ribose) polymerase (ADPRP).

• 2506850(NAD): Poly(ADP-ribose) polymerase inhibits DNA synthesis initiation in the absence of NAD.

  Poly (ADP-ribose) polymerase (ADPRP) is a nuclear enzyme that transfers ADP-ribose from NAD + to diverse nuclear proteins.

• 2452600(poly-ADP-ribose): Enhancement of bleomycin activity by 3-aminobenzamide, a poly (ADP-ribose) synthesis inhibitor, in vitro and in vivo.

  The degree of inhibition of poly (ADP-ribose) synthesis by these inhibitors corresponded in general with their potentiating ability of bleomycin cytotoxicity.