MCP-2→Recombinant Proteins→Oligonucleotide Probes→poly-ADP-ribose

• 9119400(MCP-2): The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2.

  The amplified genomic MCP-2 fragment was used to isolate an MCP-2 cosmid from which the gene sequence was determined.

• 7657606(Recombinant Proteins): Structure and promoter characterization of the human stromelysin-3 gene.

  Analysis of 1.4 kb of 5 ' - flanking DNA sequence in the ST3 gene promoter revealed the presence of putative regulatory elements , but no consensus sequence for AP1-binding site in contrast to other MMP promoters.

• 2108670(Oligonucleotide Probes): Characterization of a putative promoter region of the human poly(ADP-ribose) polymerase gene: structural similarity to that of the DNA polymerase beta gene.

  The 5 ' - flanking region of poly (ADP-ribose) polymerase gene also showed promoter activity in chloramphenicol acetyltransferase assay and structural similarity to that of DNA polymerase beta gene.

• 10570184(poly-ADP-ribose): Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion.

  Poly (ADP-ribose) polymerase (PARP) , a nuclear enzyme activated by DNA strand breaks , physiologically participates in DNA repair.