IL-8→Tumor Necrosis Factor-alpha→Interferon-gamma→Tumor Necrosis Factor-alpha→STAT2

• 17559628(IL-8): Comparison of experimental gingivitis with persistent gingivitis: differences in clinical parameters and cytokine concentrations.

  CONCLUSION : The data indicate that conditions observed after 4 wk of experimental gingivitis are not comparable with persistent gingival inflammation in a naturalistic setting.

• 18973545(Tumor Necrosis Factor-alpha): Cytokines differentially regulate CXCL10 production by interferon-gamma-stimulated or tumor necrosis factor-alpha-stimulated human gingival fibroblasts.

  In this study we examined the effects of cytokines on CXCL10 production by human gingival fibroblasts.

• 10805218(Interferon-gamma): Induction of interferon gamma in human gingival fibroblasts challenged with phytohaemagglutinin.

  We conclude that human gingival fibroblasts not only transcribe IFN-gamma mRNA but also produce the IFN-gamma protein in response to PHA.

• 2121799(Tumor Necrosis Factor-alpha): Induction and regulation of class II major histocompatibility complex mRNA expression in astrocytes by interferon-gamma and tumor necrosis factor-alpha.

  Astrocytes do not constitutively express mRNA for class II MHC.

• 11952149(STAT2): Interferon type I downregulates human parainfluenza virus type 3-induced major histocompatibility complex class II expression.

  Here we report that IFN-alpha/beta also inhibits the CIITA-independent expression of HPIV3-induced MHC class II.