IL-8→NF-kappa B→BRCA1

• 17711487(IL-8): Suppression of lipopolysaccharide- and tumour necrosis factor-alpha-induced interleukin (IL)-8 expression by glucocorticoids involves changes in IL-8 promoter acetylation.

  LPS and TNF-alpha induced IL-8 release in all three cell lines and this induction was inhibited by both dexamethasone and triamcinolone.

• 12162440(NF-kappa B): Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation.

  Oxidants and inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha) activate nuclear factor kappa B (NF-kappaB) and activator protein-1 (AP-1) transcription factors , and enhance the expression of both pro-inflammatory and protective antioxidant genes.

• 9619837(BRCA1): The BRCA2 is a histone acetyltransferase.

  Patients carrying mutations in BRCA1 or BRCA2 tumor suppressor genes have shown to have high risk in developing breast and ovarian cancers.