IL-8→Tumor Necrosis Factor-alpha→Interleukin-6→CREB

• 17727318(IL-8): High plasma levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) and interleukin-8 (IL-8) characterize patients prone to ventricular fibrillation complicating myocardial infarction.

  The markers of interest were TIMP-1 , MMP-9 and IL-8.

• 15458430(Tumor Necrosis Factor-alpha): TNF-alpha and IL-1beta-mediated regulation of MMP-9 and TIMP-1 in renal proximal tubular cells.

  Cotreatment with IL-1beta abolished the induction of MMP-9 but augmented the inhibition of TIMP-1 in the presence of TNF-alpha.

• 9516466(Interleukin-6): Transcriptional roles of CCAAT/enhancer binding protein-beta, nuclear factor-kappaB, and C-promoter binding factor 1 in interleukin (IL)-1beta-induced IL-6 synthesis by human rheumatoid fibroblast-like synoviocytes.

  Site-specific mutagenesis analysis demonstrated that the NF-kappaB and CBF1 binding elements regulated inducible activity of the IL-6 promoter in response to IL-1beta stimulation , whereas the C/EBPbeta binding element mainly regulated basal activity.

• 20452968(CREB): CCAAT/Enhancer-binding protein beta DNA binding is auto-inhibited by multiple elements that also mediate association with p300/CREB-binding protein (CBP).

  We also suggest a mechanism for C/EBPbeta derepression involving several recently identified modifications within AID and CRD.