IL-8→Interleukin-8→Interleukin-8→NF-KB

• 17869651(IL-8): Association of IL-8 (-251)T/A polymorphism with susceptibility to and aggressiveness of nasopharyngeal carcinoma.

  In the present study , we evaluated the susceptibility and prognostic implications of the (-251) T/A genetic variation in IL-8 in NPC.

• 7930675(Interleukin-8): Interleukin-8 production is regulated by protein kinase C in human keratinocytes.

  As such , auranofin was also studied for its effect on IL-8 production.

• 17786963(Interleukin-8): Differential signaling mechanisms of HNP-induced IL-8 production in human lung epithelial cells and monocytes.

  Treatment with the p38 inhibitor SB203580 attenuated the HNP-induced IL-8 production only in monocytes.

• 20197690(NF-KB): Fatty acid-bearing albumin induces VCAM-1 expression through c-Src kinase-AP-1/NF-kB pathways: effect of L-carnitine.

  RESULTS : FA (+) albumin induced VCAM-1 expression via activation of AP-1 and NF-kappaB , which was mediated through activation of c-Src kinase , followed by MAP kinases (p38 , ERK 1/2 , JNK-1) and IkappaB kinase and IkappaB-alpha , respectively.