IL-8→NF-kappa B→NF-kappa B→c-jun

• 17903420(IL-8): Morphometric analysis of proinflammatory cytokines in mammary glands of sows suggests an association between clinical mastitis and local production of IL-1beta, IL-6 and TNF-alpha.

  Twelve healthy primiparous sows received intramammary inoculation with Escherichia coli (serotype O127) during the 24-h period preceding parturition.

• 18241210(NF-kappa B): In vivo imaging of NF-kappaB activity during Escherichia coli-induced mammary gland infection.

  In mammary gland infections , the contribution of NF-kappaB is not well defined , and was therefore investigated following intramammary inoculation of Escherichia coli.

• 9252186(NF-kappa B): A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.

  IKK turns out to be the long-sought-after protein kinase that mediates the critical regulatory step in NF-kappaB activation.

• 20028971(c-jun): c-Jun N-terminal kinase enhances MST1-mediated pro-apoptotic signaling through phosphorylation at serine 82.

  However , the upstream regulators of MST1 kinase have been poorly studied.