IL-8→NF-kappa B→Interleukin-8→STAT2

• 17912013(IL-8): Endoscopic ultrasound and IL-8 in pancreatic juice to diagnose chronic pancreatitis.

  CP was diagnosed when PJ (IL-8) was) 20 pg/ml.

• 11768272(NF-kappa B): Antioxidants inhibit cytokine production and suppress NF-kappaB activation in CAPAN-1 and CAPAN-2 cell lines.

  Generally , suppression of NF-kappaB activation correlated well with inhibition of IL-6 and IL-8 secretion.

• 8971048(Interleukin-8): Inhibition of viral replication reverses respiratory syncytial virus-induced NF-kappaB activation and interleukin-8 gene expression in A549 cells.

  These data confirm that viral replication is a key step in RSV-induced NF-kappaB activation and IL-8 production.

• 15994826(STAT2): Respiratory syncytial virus nonstructural proteins NS1 and NS2 mediate inhibition of Stat2 expression and alpha/beta interferon responsiveness.

  Here we show that RSV preferentially inhibits IFN-alpha/beta signaling by expression of viral NS1 and NS2.