IL-8→Toll-Like Receptor 4→Cytokines→NF-KB

• 17912013(IL-8): Endoscopic ultrasound and IL-8 in pancreatic juice to diagnose chronic pancreatitis.

  We compared the accuracy of PJ (IL-8) and endoscopic ultrasound (EUS) to diagnose chronic pancreatitis (CP).

• 17124436(Toll-Like Receptor 4): Polymorphism in the IL-8 gene, but not in the TLR4 gene, increases the severity of acute pancreatitis.

  CONCLUSIONS : Determination of the frequency of IL-8 polymorphism in acute pancreatitis may be informative and may provide further evidence concerning the role of IL-8 in the severe form of this disease.

• 20397261(Cytokines): Different profiles of cytokine expression during mild and severe acute pancreatitis.

  Severe acute pancreatitis is associated with a typical systemic inflammatory response syndrome and over-expression of pro-inflammatory cytokines (interleukin (IL) -6 , IL-8 , macrophage migration inhibitory factor (MIF)).

• 20200229(NF-KB): Cross-regulation of cytokine signalling: pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation.

  In our study we discovered a new mechanism that answers the long-standing question how pro-inflammatory cytokines and environmental stress restrict immediate signalling of interleukin (IL) -6 - type cytokines.