IL-8→NF-kappa B→NF-kappa B→c-jun

• 17912013(IL-8): Endoscopic ultrasound and IL-8 in pancreatic juice to diagnose chronic pancreatitis.

  CP was diagnosed when PJ (IL-8) was) 20 pg/ml.

• 11768272(NF-kappa B): Antioxidants inhibit cytokine production and suppress NF-kappaB activation in CAPAN-1 and CAPAN-2 cell lines.

  Generally , suppression of NF-kappaB activation correlated well with inhibition of IL-6 and IL-8 secretion.

• 17607549(NF-kappa B): Hyaluronan inhibits cytokine production by lipopolysaccharide-stimulated U937 macrophages through down-regulation of NF-kappaB via ICAM-1.

  Inhibition studies revealed the requirement of NF-kappaB for LPS-stimulated cytokine production.

• 20299009(c-jun): IFNgamma primes macrophages for inflammatory activation by high molecular weight hyaluronan.

  IFNgamma modulates the HMW-HA-induced cytokine response profile promoting macrophage activation and inflammatory TH1 cytokine secretion.