IL-8→Transforming Growth Factor beta→Transforming Growth Factors→JunD

• 17993253(IL-8): Release of MCP-1 and IL-8 from lung epithelial cells exposed to volatile organic compounds.

  Mixtures of aromatic compounds caused comparable effects to the single compounds on MCP-1 and IL-8 with a shift to lower concentration ranges.

• 16204411(Transforming Growth Factor beta): TGF-beta1 induces IL-8 and MCP-1 through a connective tissue growth factor-independent pathway.

  TGF-beta (1) induced an increase in IL-8 and MCP-1 (both P (0.05) compared with control levels.

• 2108318(Transforming Growth Factors): Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.

  These results demonstrate that both components of the AP-1 complex are required for TGF-beta 1 autoinduction.

• 1429597(JunD): Transcriptional cross-talk: nuclear factors CREM and CREB bind to AP-1 sites and inhibit activation by Jun.

  AP-1 binds to 12-O-tetradecanoylphorbol-13-acetate-responsive elements (TREs) palindromic sequences.