IL-8→Interleukin-8→Interleukin-8→NF-KB

• 18212111(IL-8): Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes.

  The production of interleukin-8 induced by the activation of protease-activated receptor 2 and its synergism with interleukin-1beta were modulated by 14-membered-ring macrolides , namely , roxithromycin , erythromycin , and clarithromycin , in cultured normal human epidermal keratinocytes.

• 12009185(Interleukin-8): Localization of the chemokine interleukin-8 and interleukin-8 receptors in human gingiva and cultured gingival keratinocytes.

  In vitro studies verified the above results , by showing expression of IL-8 and IL-8R in cultured gingival keratinocytes.

• 9079743(Interleukin-8): Role of interleukin-8 in onset of the immune response in intravesical BCG therapy for superficial bladder cancer.

  The appearance of IL-8 in patients urine after BCG therapy was compared with BCG-induced IL-6 and IL-2 and the stability of IL-8 in urine was tested.

• 20470938(NF-KB): IL-8 -251 T > A polymorphism is associated with bladder cancer susceptibility and outcome after BCG immunotherapy in a northern Indian cohort.

  Of these , 71 patients were treated with BCG immunotherapy.